Established in 1976 by a group of artists, many of them ex-Ruskin School of Drawing students to create a venue where they could continue their work.

After a long search the current premises were leased from the Christadelphian Church in 1977 helped by a grant from Southern Arts of £3,000.

The transformation of the premises into a print workshop was undertaken voluntarily by OPC members. On 11 February 1978, a formal constitution having been developed, and the workshop registering with the Industrial and Provident Societies a co-operative status established, the workshop officially opened. In autumn 1978 OPC held the first print workshop.

A National Lottery grant in 1995 enabled OPC to buy badly needed equipment.

Oxford Printmakers regularly participates in exhibitions around the UK and overseas.